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KMID : 1094020120290060441
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Journal of Veterinary Clinics
2012 Volume.29 No. 6 p.441 ~ p.446
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The Protective Effect of Ginger Aqueous Extracts on CCl₄-induced Hepatic Damage in Mice
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Koo Sung-wook
Lee Keun-Woo
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Abstract
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The purpose of present study is to observe the hepato-protective effect of ginger aqueous extracts on carbon tetrachloride(CCl₄)-induced mouse. Ginger groups received ginger aqueous extracts (500 mg/kg) orally for 3 days and given a single dose of CCl₄ (4 mL/kg). Silymarin group was treated with silymarin (50 mg/kg) orally for 3 days and then aministration of CCl₄ (4 mL/kg). Control group was only administered CCl₄ (4 mL/kg). In the ginger groups, the AST, ALT levels were significantly (p < 0.05) decreased compared to the control groups. Histopathological evaluation, hepatic parenchyma and kidney parenchyma of ginger groups were significantly (p < 0.05) decreased compared to control group. The results obtained in this study suggest that ginger aqueous extracts are able to protect the liver CCl₄-induced injury.
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KEYWORD
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CCl₄, ginger, liver, mouse
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